Job Description

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Simeonov Lab at Fred Hutchinson Cancer Center is recruiting a highly motivated Post-Doctoral Research Fellow to join a new interdisciplinary group studying cancer evolution, metastasis, and therapy resistance using molecular recorders – tools that enable cells to log aspects of their own biology directly into their DNA.

The lab combines experimental and computational approaches to develop and apply barcode-based lineage recording systems, single-cell technologies, and perturbation tools to uncover the principles of tumor evolution at high-resolution. Technologies, such as macsGESTALT , along with next-generation molecular recorders in development, enable the generation of massive-scale, novel datasets that open new windows into cancer dynamics and allow us to address previously inaccessible questions (see example figure above).

We welcome candidates eager to harness or advance these tools to illuminate fundamental drivers of metastasis, drug resistance, and other key cancer outcomes. Projects will be tailored to the candidate’s strengths and interests, with multiple creative, high-impact directions available. We value a collaborative, rigorous lab culture and are deeply committed to scientific growth. Applicants with hybrid wet and dry lab expertise are especially encouraged, as are those with deep skills in one domain who are motivated to expand into the other. We also welcome purely computational applicants with interests in phylogenetics or advanced single-cell analysis, as well as purely experimental applicants with strong backgrounds in synthetic biology or molecular tool development.

Responsibilities

• Engineering and developing novel molecular recorder systems
• Designing and executing in vitro and in vivo experiments and generating single-cell sequencing data
• Analyzing recorder outputs and high-dimensional datasets to study cancer evolution
• Presenting and preparing results for publication

Qualifications

MINIMUM QUALIFICATIONS:

• PhD (or equivalent) in biology, bioengineering, computer science, physics, or a related field
• Strong scientific curiosity, motivation, and rigor
• Strong communication, organizational, and analytical skills

PREFERRED QUALIFICATIONS:

• Molecular/synthetic biology, single-cell sequencing, or in vivo cancer models
• Evolving or static barcode-based lineage tracing
• Computational analysis of high-dimensional data (e.g., single-cell RNA-seq, phylogenetics, spatial data)
• Experience in R or Python

Application instructions:
Please send a CV, a brief cover letter describing your research interests and career goals.

The annual base salary range for this position is from $77,976 to $95,014, and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).

Company

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network.  Careers Start Here.

At Fred Hutch, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit of, and passion for, health knowledge and hope to their work and the world. Together, our researchers are discovering new ways to detect cancers earlier, when cure rates are highest; developing effective treatments with fewer side effects; and learning how to prevent cancers from growing in the first place.

Our groundbreaking discoveries began in the 1970s with Dr. E. Donnall Thomas’s pioneering work in bone marrow transplantation, which led to him receiving the 1990 Nobel Prize in physiology or medicine. Since then, Hutch researchers have made a number of breakthroughs, including developing immunotherapies that use the immune system to defeat cancer and advancing the understanding of human biology. 

Admittedly, the eradication of cancer and other life-threatening diseases is an ambitious goal, one that demands tenacity, scientific excellence, collaboration and breakthrough creativity. To accomplish this, Fred Hutch attracts some of the world's greatest minds.

Our roster of internationally acclaimed scientists includes a MacArthur fellow, members of the National Academy of Sciences, members of the Institute of Medicine, members of the American Academy of Arts and Sciences, members of the American Association for the Advancement of Science and current and former Howard Hughes Medical Institute investigators.

Fred Hutch understands that disease research means more than searching for new treatments. We are home to the country's largest and oldest cancer prevention program, which has made key contributions to understanding how diet, exercise and other factors reduce the risk of acquiring the disease.

To accelerate our progress, we are part of the Fred Hutch / University of Washington Cancer Consortium. This research and clinical collaboration between the Hutch, the University of Washington, Seattle Children’s and Seattle Cancer Care Alliance enables our researchers to leverage each institution’s strengths and develop premier research programs across many types of disease. The Consortium is among 49 National Cancer Institute-designated comprehensive cancer centers nationwide.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Company info

Location

Seattle
WA
98109
United States

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